Isaac Guerendo.

Isaac Guerendo is a running back for the San Francisco 49ers, wearing number 31 in one of the NFL's most run-heavy offensive systems. He stands 6 feet tall and weighs 221 pounds, giving him a sturdy frame that suits both between-the-tackles running and pass protection duties. Guerendo played college football at Louisville before making his way to San Francisco's backfield depth chart.

Across 16 games played in the 2024 season, Guerendo saw action in a 49ers offense that has historically cycled through multiple running backs based on health and game script. San Francisco's committee backfield approach means carries and targets can shift week to week, which is a key consideration for bettors. For prop bet purposes, rushing attempts, receiving targets, and total yards are the most relevant markets to track for a back in this system. Because the 49ers distribute touches across several backs, monitoring weekly injury reports and snap count trends is essential before placing rushing yards or anytime touchdown props on Guerendo. His size and versatility make him a candidate for goal-line work when opportunities arise, and any increase in snap share due to injuries to backfield teammates can quickly elevate his statistical ceiling for a given week.