Ke’Shawn Vaughn.

Ke'Shawn Vaughn is a running back on the San Francisco 49ers roster, serving as a depth option in one of the NFL's most backfield-heavy offensive systems. He stands 5 feet 10 inches and weighs 214 pounds, a sturdy build for the position. Vaughn played college football at Vanderbilt before entering the NFL, where he spent several seasons with the Tampa Bay Buccaneers developing as a reserve contributor before landing in San Francisco.

Through 3 games played in the 2024 season, Vaughn has seen limited action as a situational back behind a crowded depth chart that includes established names at the position. His role is primarily that of a reserve and special teams contributor, meaning his offensive opportunities tend to be sporadic and situation-dependent. For bettors, Vaughn is not a consistent target for standard rushing or receiving prop bets given his depth status. However, in the event of injuries to players ahead of him on the depth chart, his usage could shift quickly, making him a name worth monitoring throughout the season. The 49ers run a complex, high-volume rushing offense, so any meaningful elevation in Vaughn's role would carry real prop bet relevance for carries, rushing yards, and receiving targets out of the backfield. Tracking his status on the weekly injury report is the most practical approach for bettors with interest in his potential involvement.